Voinsky, I., Bennuri, S.C., Svigals, J. et al. Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism. Sci Rep 9, 13443 (2019). https://doi.org/10.1038/s41598-019-49617-9

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Shimasaki C, Frye RE, Trifiletti R, Cooperstock M, Kaplan G, Melamed I, Greenberg R, Katz A, Fier E, Kem D, Traver D, Dempsey T, Latimer ME, Cross A, Dunn JP, Bentley R, Alvarez K, Reim S, Appleman J. Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms. J Neuroimmunol. 2020 Feb 15;339:577138. doi: 10.1016/j.jneuroim.2019.577138. Epub 2019 Dec 15. PMID: 31884258.

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Singh K, Singh IN, Diggins E, Connors SL, Karim MA, Lee D, Zimmerman AW, Frye RE. Ann Clin Transl Neurol. 2020 May;7(5):683-694. doi: 10.1002/acn3.51034. Epub 2020 Apr 28. PMID: 32343046; PMCID: PMC7261756.

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Frye RE. Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments. Semin Pediatr Neurol. 2020 Oct;35:100829. doi: 10.1016/j.spen.2020.100829. Epub 2020 Jun 23. PMID: 32892956.

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Frye RE, Cakir J, Rose S, Delhey L, Bennuri SC, Tippett M, Palmer RF, Austin C, Curtin P, Arora M. Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder. Transl Psychiatry. 2020 Jul 7;10(1):223. doi: 10.1038/s41398-020-00905-3. PMID: 32636364; PMCID: PMC7341836.

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Frye RE, Cakir J, Rose S, Delhey L, Bennuri SC, Tippett M, Melnyk S, James SJ, Palmer RF, Austin C, Curtin P, Arora M. Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology. Mol Psychiatry. 2021 May;26(5):1561-1577. doi: 10.1038/s41380-020-00885-2. Epub 2020 Sep 22. PMID: 32963337; PMCID: PMC8159748.

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Rossignol DA, Frye RE. Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis. J Pers Med. 2021 Nov 3;11(11):1141. doi: 10.3390/jpm11111141. Erratum in: J Pers Med. 2022 Apr 29;12(5): PMID: 34834493; PMCID: PMC8622150.

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Frye RE, Cakir J, Rose S, Palmer RF, Austin C, Curtin P, Arora M. Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder. J Pers Med. 2021 Mar 18;11(3):218. doi: 10.3390/jpm11030218. PMID: 33803789; PMCID: PMC8003154.

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Zimmerman AW, Singh K, Connors SL, Liu H, Panjwani AA, Lee LC, Diggins E, Foley A, Melnyk S, Singh IN, James SJ, Frye RE, Fahey JW. Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder. Mol Autism. 2021 May 25;12(1):38. doi: 10.1186/s13229-021-00447-5. Erratum in: Mol Autism. 2021 Jun 16;12(1):44. PMID: 34034808; PMCID: PMC8146218.

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Frye RE, Vassall S, Kaur G, Lewis C, Karim M, Rossignol D. Emerging biomarkers in autism spectrum disorder: a systematic review. Ann Transl Med. 2019 Dec;7(23):792. doi: 10.21037/atm.2019.11.53. PMID: 32042808; PMCID: PMC6989979.

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Barone R, Bastin J, Djouadi F, Singh I, Karim MA, Ammanamanchi A, McCarty PJ, Delhey L, Shannon R, Casabona A, Rizzo R, Frye RE. Mitochondrial Fatty Acid β-Oxidation and Resveratrol Effect in Fibroblasts from Patients with Autism Spectrum Disorder. J Pers Med. 2021 Jun 4;11(6):510. doi: 10.3390/jpm11060510. PMID: 34199819; PMCID: PMC8229571.

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Frye RE, Cakir J, Rose S, Palmer RF, Austin C, Curtin P. Physiological mediators of prenatal environmental influences in autism spectrum disorder. Bioessays. 2021 Sep;43(9):e2000307. doi: 10.1002/bies.202000307. Epub 2021 Jul 14. PMID: 34260745.

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Rossignol DA, Frye RE. A Systematic Review and Meta-Analysis of Immunoglobulin G Abnormalities and the Therapeutic Use of Intravenous Immunoglobulins (IVIG) in Autism Spectrum Disorder. J Pers Med. 2021 May 30;11(6):488. doi: 10.3390/jpm11060488. PMID: 34070826; PMCID: PMC8229039.

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Pines AR, Sussman B, Wyckoff SN, McCarty PJ, Bunch R, Frye RE, Boerwinkle VL. Locked-in Intact Functional Networks in Children with Autism Spectrum Disorder: A Case-Control Study. J Pers Med. 2021 Aug 28;11(9):854. doi: 10.3390/jpm11090854. PMID: 34575631; PMCID: PMC8465896.

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Frye RE, Rose S, McCullough S, Bennuri SC, Porter-Gill PA, Dweep H, Gill PS. MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation. J Pers Med. 2021 Sep 17;11(9):922. doi: 10.3390/jpm11090922. PMID: 34575699; PMCID: PMC8469245.

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McCarty PJ, Pines AR, Sussman BL, Wyckoff SN, Jensen A, Bunch R, Boerwinkle VL, Frye RE. Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder. J Pers Med. 2021 Sep 28;11(10):969. doi: 10.3390/jpm11100969. PMID: 34683111; PMCID: PMC8537605.

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Rossignol DA, Frye RE. The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. J Pers Med. 2021 Aug 11;11(8):784. doi: 10.3390/jpm11080784. PMID: 34442428; PMCID: PMC8400809.

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McCarty PJ, Pines AR, Sussman BL, Wyckoff SN, Jensen A, Bunch R, Boerwinkle VL, Frye RE. Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder. J Pers Med. 2021 Sep 28;11(10):969. doi: 10.3390/jpm11100969. PMID: 34683111; PMCID: PMC8537605.

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Frye RE, Lionnard L, Singh I, Karim MA, Chajra H, Frechet M, Kissa K, Racine V, Ammanamanchi A, McCarty PJ, Delhey L, Tippett M, Rose S, Aouacheria A. Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder. Transl Psychiatry. 2021 Oct 13;11(1):527. doi: 10.1038/s41398-021-01647-6. PMID: 34645790; PMCID: PMC8514530.

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Adams, J.B.; Bhargava, A.; Coleman, D.M.; Frye, R.E.; Rossignol, D.A. Ratings of the Effectiveness of Nutraceuticals for Autism Spectrum Disorders: Results of a National Survey. J. Pers. Med. 2021, 11, 878. https://doi.org/10.3390/jpm11090878

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Foldes ST, Jensen AR, Jacobson A, Vassall S, Foldes E, Guthery A, Brown D, Levine T, Tyler WJ, Frye RE. Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings. J Pers Med. 2021 Dec 6;11(12):1307. doi: 10.3390/jpm11121307. PMID: 34945779; PMCID: PMC8704341.

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Berry-Kravis E, Filipink RA, Frye RE, Golla S, Morris SM, Andrews H, Choo TH, Kaufmann WE; FORWARD Consortium. Seizures in Fragile X Syndrome: Associations and Longitudinal Analysis of a Large Clinic-Based Cohort. Front Pediatr. 2021 Dec 30;9:736255. doi: 10.3389/fped.2021.736255. PMID: 35036394; PMCID: PMC8756611.

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Frye RE. A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder. J Pers Med. 2022 Mar 14;12(3):464. doi: 10.3390/jpm12030464. PMID: 35330464; PMCID: PMC8949394.

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Werner BA, McCarty PJ, Lane AL, Singh I, Karim MA, Rose S, Frye RE. Time dependent changes in the bioenergetics of peripheral blood mononuclear cells: processing time, collection tubes and cryopreservation effects. Am J Transl Res. 2022 Mar 15;14(3):1628-1639. PMID: 35422946; PMCID: PMC8991115.

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Gill, P.S.; Dweep, H.; Rose, S.; Wickramasinghe, P.J.; Vyas, K.K.; McCullough, S.; Porter-Gill, P.A.; Frye, R.E. Integrated microRNA–mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism. J. Pers. Med. 2022, 12, 920. https://doi.org/10.3390/jpm12060920

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Brister D, Werner BA, Gideon G, McCarty PJ, Lane A, Burrows BT, McLees S, Adelson PD, Arango JI, Marsh W, Flores A, Pankratz MT, Ly NH, Flood M, Brown D, Carpentieri D, Jin Y, Gu H, Frye RE. Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis. Metabolites. 2022 Apr 20;12(5):371. doi: 10.3390/metabo12050371. PMID: 35629876; PMCID: PMC9148155.

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Rossignol DA, Frye RE. Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis. J Pers Med. 2021 Nov 3;11(11):1141. doi: 10.3390/jpm11111141. Erratum in: J Pers Med. 2022 Apr 29;12(5): PMID: 34834493; PMCID: PMC8622150.

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Jensen AR, Lane AL, Werner BA, McLees SE, Fletcher TS, Frye RE. Modern Biomarkers for Autism Spectrum Disorder: Future Directions. Mol Diagn Ther. 2022 Sep;26(5):483-495. doi: 10.1007/s40291-022-00600-7. Epub 2022 Jun 27. PMID: 35759118; PMCID: PMC9411091.

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Voinsky, I.; Zoabi, Y.; Shomron, N.; Harel, M.; Cassuto, H.; Tam, J.; Rose, S.; Scheck, A.C.; Karim, M.A.; Frye, R.E.; Aran, A.; Gurwitz, D. Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder. Int. J. Mol. Sci. 2022, 23, 9843. https://doi.org/10.3390/ijms23179843

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Brister D, Rose S, Delhey L, Tippett M, Jin Y, Gu H, Frye RE. Metabolomic Signatures of Autism Spectrum Disorder. J Pers Med. 2022 Oct 17;12(10):1727. doi: 10.3390/jpm12101727. PMID: 36294866; PMCID: PMC9604590.

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Frye RE, Cakir J, McCarty PJ, Rose S, Delhey LM, Palmer RF, Austin C, Curtin P, Yitshak-Sade M, Arora M. Air Pollution and Maximum Temperature Are Associated with Neurodevelopmental Regressive Events in Autism Spectrum Disorder. J Pers Med. 2022 Nov 1;12(11):1809. doi: 10.3390/jpm12111809. PMID: 36579525; PMCID: PMC9696106.

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Jyonouchi, H.; Geng, L.; Rossignol, D.A.; Frye, R.E. Long COVID Syndrome Presenting as Neuropsychiatric Exacerbations in Autism Spectrum Disorder: Insights for Treatment. J. Pers. Med. 2022, 12, 1815. https://doi.org/10.3390/jpm12111815

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Frye RE, Lane A, Worner A, Werner BA, McCarty PJ, Scheck AC, Collins HL, Adelman SJ, Quadros EV, Rossignol DA. The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment. J Pers Med. 2022 Dec 8;12(12):2033. doi: 10.3390/jpm12122033. PMID: 36556254; PMCID: PMC9786140.

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Senarathne, U.D.; Indika, N.-L.R.; Jezela-Stanek, A.; Ciara, E.; Frye, R.E.; Chen, C.; Stepien, K.M. Biochemical, Genetic and Clinical Diagnostic Approaches to Autism-Associated Inherited Metabolic Disorders. Genes 2023, 14, 803. https://doi.org/10.3390/genes14040803

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Frye, R.E.; Nanda, H.; Pleasure, S.J.; Casanova, M.F.; Boles, R.G.; Lewine, J.; Gaitanis, J.; Adams, J.B. Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable. J. Pers. Med. 2023, 13, 557. https://doi.org/10.3390/jpm13030557

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Frye, R.E.; Nanda, H.; Pleasure, S.J.; Casanova, M.F.; Boles, R.G.; Lewine, J.; Gaitanis, J.; Adams, J.B. Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable. J. Pers. Med. 2023, 13, 557. https://doi.org/10.3390/jpm13030557

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Frye, RE. The Autism File: Biomedical Update. 2015. pp. 28-34.

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Frye, RE, Casanova M, Brown GL, Martin V, Edelson S, Coben R, Lewine J, Rossignol D, MacFabe D, Slattery J, Adams JB. Autism Science Digest: The Journal of Autismone. Issue 5. pp. 4-10.

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Frye, RE, Slattery J, Adams JB. The Autism File: Biomedical Update. pp. 24-29.

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Frye, RE, Rossignol D. Autism Science Digest: The Journal of Autismone. Issue 2. pp. 9-15.

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Frye, RE. Autism File: Autism & Treatments. 2017. pp. 25-29.

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Neurological Health Foundation. 2019.

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Posted by: TACA Now Blog
Posted on:  March 29, 2023

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Rossignol, DA, Frye, RE. Autism Science Digest: The Journal of Autismone. 2011. pp. 21-27.

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Frye, RE, Rose S. Autism File. June-July 2017. pp. 18-21.

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Brister D, Rose S, Delhey L, Tippett M, Jin Y, Gu H, Frye RE. Metabolomic Signatures of Autism Spectrum Disorder. J Pers Med. 2022 Oct 17;12(10):1727. doi: 10.3390/jpm12101727. PMID: 36294866; PMCID: PMC9604590.

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